PRECLINICAL EVIDENCE FOR EMPLOYING MEK INHIBITION IN NRAS MUTATED PEDIATRIC GASTROENTEROPANCREATIC NEUROENDOCRINE-LIKE TUMORS

Preclinical evidence for employing MEK inhibition in NRAS mutated pediatric gastroenteropancreatic neuroendocrine-like tumors

Background: Pediatric gastroenteropancreatic neuroendocrine tumors are exceedingly rare, resulting in most pediatric treatment recommendations being based on data derived from adults.Trametinib is a kinase inhibitor that targets MEK1/2 and has been employed in the treatment of Sanding Accessories cancers harboring mutations in the Ras pathway.Metho

read more

Lesbian, gay or bisexual identity as a risk factor for trauma and mental health problems in Northern Irish students and the protective role of social support

Background: People identifying as lesbian, gay or bisexual (LGB) have been shown to experience more trauma and poorer mental health than their heterosexual counterparts, particularly in countries with discriminatory laws and policies.Northern Ireland is a post-conflict region with high rates of trauma and mental health problems, as well as signific

read more

The analysis of expenses of a regional budget incidental to providing oncologic patients with narcotic analgesics during the out-patient period of treatment (on the example of Nizhny Novgorod region)

This article presents the analysis of narcotic analgesics (NA) cost for the treatment of chronic pain syndrome (CPS) in oncologic patients, paid for with the funds of regional budget of the Nizhny Novgorod region in 2010-2014.The analysis was performed using the electronic prescriptions money box database.In total, during the abovementioned period,

read more

ABCDE of prehospital ultrasonography: a narrative review

Abstract Prehospital point-of-care Curl shampoo ultrasound used by nonradiologists in emergency medicine is gaining ground.It is feasible on-scene and during aeromedical transport and allows health-care professionals to detect or rule out potential harmful conditions.Consequently, it impacts decision-making in prioritizing care, selecting the best

read more